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PDF) Evaluation of the abuse potential of difelikefalin, a selective kappa‐ opioid receptor agonist, in recreational polydrug users
PDF) Evaluation of the abuse potential of difelikefalin, a selective kappa‐ opioid receptor agonist, in recreational polydrug users

Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug  Development | SpringerLink
Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development | SpringerLink

1Washington University, St. Louis, MO, USA; 2Trevi Therapeutics, New Haven,  CT, USA; 3University of Miami, Miami, FL, USA Introd
1Washington University, St. Louis, MO, USA; 2Trevi Therapeutics, New Haven, CT, USA; 3University of Miami, Miami, FL, USA Introd

Molecules | Free Full-Text | Design of κ-Opioid Receptor Agonists for  the Development of Potential Treatments of Pain with Reduced Side Effects
Molecules | Free Full-Text | Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects

Cara Therapeutics: Scratching At Multiple Indications In 2020 (NASDAQ:CARA)  | Seeking Alpha
Cara Therapeutics: Scratching At Multiple Indications In 2020 (NASDAQ:CARA) | Seeking Alpha

Cara Therapeutics - Invest In Weed
Cara Therapeutics - Invest In Weed

κ-opioid receptor - Wikipedia
κ-opioid receptor - Wikipedia

Difelikefalin - Wikipedia
Difelikefalin - Wikipedia

Modulation of the kappa and mu opioid axis for the treatment of chronic  pruritus: A review of basic science and clinical implications -  ScienceDirect
Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implications - ScienceDirect

A systematic review on the kappa opioid receptor and its ligands: New  directions for the treatment of pain, anxiety, depression, and drug abuse -  ScienceDirect
A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse - ScienceDirect

EX-99.2
EX-99.2

CR845 (Difelikefalin), A Kappa Receptors Agonist In Phase III By CARA  Therapeutics: A Case Of 'Spin' In Scientific Writing? | Semantic Scholar
CR845 (Difelikefalin), A Kappa Receptors Agonist In Phase III By CARA Therapeutics: A Case Of 'Spin' In Scientific Writing? | Semantic Scholar

Will peripherally restricted kappa‐opioid receptor agonists (pKORAs)  relieve pain with less opioid adverse effects and abuse potential? -  Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics -  Wiley Online Library
Will peripherally restricted kappa‐opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential? - Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class  of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink
Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink

Difelikefalin: First Approval
Difelikefalin: First Approval

Nephrology Journal Club on Twitter: "Difelikefalin (CR845) (KORSUVA) is a  peripherally restricted, selective kappa opioid receptor agonist that  exerts antipruritic effects by means of activation of kappa opioid  receptors on peripheral neurons
Nephrology Journal Club on Twitter: "Difelikefalin (CR845) (KORSUVA) is a peripherally restricted, selective kappa opioid receptor agonist that exerts antipruritic effects by means of activation of kappa opioid receptors on peripheral neurons

Strategies for Developing κ Opioid Receptor Agonists for the Treatment of  Pain with Fewer Side Effects | Journal of Pharmacology and Experimental  Therapeutics
Strategies for Developing κ Opioid Receptor Agonists for the Treatment of Pain with Fewer Side Effects | Journal of Pharmacology and Experimental Therapeutics

PDF) Effect of Difelikefalin, a Selective Kappa Opioid Receptor Agonist, on  Respiratory Depression: A Randomized, Double‐Blind, Placebo‐Controlled Trial
PDF) Effect of Difelikefalin, a Selective Kappa Opioid Receptor Agonist, on Respiratory Depression: A Randomized, Double‐Blind, Placebo‐Controlled Trial

A New Path to Pain Relief: Time for a Change with a Peripherally Acting Kappa  Opioid Receptor Agonist (KORA)Friday, March 17, 201712:30 PM – 1:30 PMGrand  Caribbean Ballroom 7Loews Sapphire Falls ResortOrlando, Florida Survey
A New Path to Pain Relief: Time for a Change with a Peripherally Acting Kappa Opioid Receptor Agonist (KORA)Friday, March 17, 201712:30 PM – 1:30 PMGrand Caribbean Ballroom 7Loews Sapphire Falls ResortOrlando, Florida Survey

New Kappa-Opioid Receptor Agonist Curbs Pain, Avoids Side Effects
New Kappa-Opioid Receptor Agonist Curbs Pain, Avoids Side Effects

Will peripherally restricted kappa‐opioid receptor agonists (pKORAs)  relieve pain with less opioid adverse effects and abuse potential? -  Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics -  Wiley Online Library
Will peripherally restricted kappa‐opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential? - Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

Pharmaceuticals | Free Full-Text | Therapeutic Potential of Kappa Opioid  Agonists
Pharmaceuticals | Free Full-Text | Therapeutic Potential of Kappa Opioid Agonists

Peripheral kappa opioid receptor activation drives cold hypersensitivity in  mice | bioRxiv
Peripheral kappa opioid receptor activation drives cold hypersensitivity in mice | bioRxiv